Cross-Reactivity and Neutralizing Ability of Monoclonal Antibodies against Microcystins
نویسندگان
چکیده
منابع مشابه
Derivation of neutralizing monoclonal antibodies against rotavirus.
Monoclonal antibodies were derived against the SA11 simian, NIC bovine, and Wa human rotavirus strains and characterized by enzyme-linked immunosorbent assay, plaque neutralization, and hemagglutination inhibition. Several strain SA11-specific antibodies were found to have neutralizing and hemagglutination-inhibiting capacity.
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BACKGROUND Only Clostridium botulinum strain IBCA10-7060 produces the recently described novel botulinum neurotoxin type H (BoNT/H). BoNT/H (N-terminal two-thirds most homologous to BoNT/F and C-terminal one-third most homologous to BoNT/A) requires antitoxin to toxin ratios ≥1190:1 for neutralization by existing antitoxins. Hence, more potent and safer antitoxins against BoNT/H are needed. M...
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Some members of the gamma herpesvirus genus Macavirus are maintained in nature as subclinical infections in well-adapted ungulate hosts. Transmission of these viruses to poorly adapted hosts, such as American bison and cattle, can result in the frequently fatal disease malignant catarrhal fever (MCF). Based on phylogenetic analysis, the MCF viruses (MCFV) cluster into two subgroups correspondin...
متن کامل3. Antibodies and antigens: cross-reactivity before monoclonal antibodies 4. Antibodies and antigens: cross-reactivity after monoclonal antibodies 5. Cross-reactivity and the molecular mimicry hypothesis 6. Cross-reactivity and the phenomenon of microbial escape from immune surveillance
1. Abstract 2. Introduction: the “vaccine problem” 3. Antibodies and antigens: cross-reactivity before monoclonal antibodies 4. Antibodies and antigens: cross-reactivity after monoclonal antibodies 5. Cross-reactivity and the molecular mimicry hypothesis 6. Cross-reactivity and the phenomenon of microbial escape from immune surveillance 7. Peptide commonality, immune escape, adjuvanted vaccines...
متن کاملNeutralizing monoclonal antibodies against three serotypes of porcine rotavirus.
Using three serotypes (four strains) of cultivable porcine rotavirus as immunizing antigens, 10 neutralizing monoclonal antibodies were characterized. One VP4-specific monoclonal antibody directed against porcine rotavirus BEN-144 (serotype G4) neutralized human rotavirus strain ST-3 in addition to the homologous porcine virus. All nine VP7-specific monoclonal antibodies were highly specific fo...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1994
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1994.tb01796.x